This research aimed to extract active substances, namely caffeine, chlorogenic acid and catechin from coffee cherries using environmentally friendly solvents based on natural deep eutectic solvent (NADES). The maximum concentration of caffeine extracted using NADES composed of choline chloride - xylose, was 264 ppm. Extraction of this substance showed varying concentrations with different composition of NADES as choline chloride with xylose > glucose > lactic acid > propylene glycol > citric acid > proline > glycerin > fructose. The maximum concentration of chlorogenic acid obtained using choline chloride- xylose, was 29.1 ppm. The extraction of chlorogenic acid indicated different concentrations with various NADES compositions using choline chloride with xylose > glucose > proline > fructose > citric acid > lactic acid > glycerol > propylene glycol. The catechin showed that the maximum extract using choline chloride-glucose with the concentration of 43 ppm.
Therefore, NADES is considered a green solvent that holds potential for application in the pharmaceutical industry for the production of various products.