Allium sativum L. (garlic) is one of the most important medicinal plants which has been used in traditional medicine for decades. There are four different varieties of garlic. One of them is called single clove garlic which differs from multi clove garlic in morphology and active constituents. Garlic contains a variety of chemical constituents including sulfur-containing phytoconstituents that cause pungent odor and taste, phenolic compounds, and saponins. Several researchers have reported on its broad-spectrum therapeutic efficacy. It has been reported as a prophylactic in cardiovascular diseases due to its antihypertensive and anti-hyperlipidemic, and to boost the immune system in addition to its antimicrobial, antibacterial, antifungal, antiviral, anticancer, and antioxidant activities. This review summarizes the difference between single and multi-clove garlic in botanical, phytochemical, ethnomedicinal, and pharmacological properties.