Background: Hospitals are forced to stay responding to environmental change nurses' readiness for change considered a key aspect of any hospital change efforts. Job enrichment is an excellent means of enhancing employee job satisfaction and prevention of staff turnover or intention to leave an organization Aim: The present study aimed to assess nursing staff readiness for change and its relation to job enrichment during hospital transformation. Design: A descriptive correlative design utilized to fulfill the study aim. Setting: The study was conducted in (Smalout Specialized Hospital at Smalout City, Minia governorate, Egypt). Subjects: convenience sample included all nursing staff working in the hospital (n=415). Data collection Tools: Personal data sheet, Nursing Staff Readiness for Change Scale and Job Enrichment Scale. Results: (89.4%) of nursing staff have moderate level regarding total Readiness for change and (70.1%) from nursing staff have "moderate" level regarding total job enrichment." Moreover, there was high statistical significance positive correlation between Readiness for Change and Job Enrichment among the studied sample (p =0.000"& "r =.283). Conclusion: readiness for change was high statistical significance with weak positive correlation to job enrichment Recommendations: Develop training modules focusing on change management, new processes, and required skills. Identify and implement job enrichment opportunities such as role diversification, decision-making authority, and professional development.