Cryptosporidiosis, an enteric disease of cattle particularly in young calves is becoming
increasingly important. It is a common and significant zoonotic gastrointestinal parasite
and a highly infectious disease and infection can occur by few numbers of oocysts. Signs
are typically characterized by copious watery diarrhea with weight loss as well as
abdominal discomfort, dehydration is very dangerous sign may cause mortalities, fatigue,
cramp, vomiting. In addition, asymptomatic infection can occur according to immune
state and age of animals. As an emergent pathogen, it developed many virulence factors
to escape from the host immune response and resist many antiprotozoal compounds,
which in turn is responsible for huge economic losses in the form of calf mortalities,
decrease milk productions, meat production. In the current study, we discussed animals
and humans' clinical implications, virulence factors, host pathogen interactions, recent
trends in prevention and control and recent developed drugs and treatment. Finally, this
comprehensive review has presented an updated view of the status and future
perspectives in the field of cryptosporidiosis, which will help in controlling it worldwide.