The present study was carried out to investigate the presence of the residues of the two most commonly used fluoroquinolones, enrofloxacin and ciprofloxacin in breast muscles, liver and kidney samples of fresh broiler chicken carcasses by using an ultra-performance liquid chromatography coupled to mass spectrometry (UPLC-MS/MS) techniques. The obtained results revealed that two samples were positive for enrofloxacin residues analysis. The first positive sample was for breast muscles and recorded 8.11 µg/kg and it was within the recommended permissible limit of muscles (100 µg/kg) commission Regulation EU/No.37 (2010). Meanwhile, the second positive sample was a kidney sample, which recorded a concentration of 579.6 µg/kg that is higher than the permissible limit for kidney (300 µg/kg) (Commission Regulation EU/No. 37, 2010). On the other hand, results showed that none of the examined samples has residues of ciprofloxacin. The possible public health risks of detected antibiotic residues were discussed.