A total of one hundred and twenty five samples, twenty five of each beef burger, frankfurter, kofta, minced meat and sausage were collected from Port-Said markets. Samples were examined to isolate and evaluate the prevalence rate of E. coli O157:H7 and other E. coli serotypes. E. coli was detected in burger, frankfurter, kofta, minced meat and sausage samples at a rate of 56, 40, 92 68 and 72%, respectively. Six (4.8%) out of all 125 tested meat products samples were found to be contaminated with E. coli O157:H7, ten isolates of E. coli O157:H7 could be recovered. A total of 50 E. coli isolates recovered from positive samples were identified to serogroups, 055 (30%), 0111 (22%), 0113 (22%), 0119 (16%), 068 (6%) and 0126 (4%). The majority of E.coli serotypes recovered from the examined samples showed hemolytic activity. The public health significant of the isolated serogroups and consumer's safety were discussed.