A total number of 40 freshly slaughter and frozen packed rabbits (20 each), including its edible offals were collected from poultry butcher shops and different markets in Port-said city. Samples from muscles and edible offals (liver, lungs, heart, and kidneys) were examined microbiologically for presence of Escherichia coli. The prevalence of   E. coli in the examined unpacked fresh rabbit samples was 40, 35, 30 and 60% with mean values of 8.7x10², 5.0x10², 3.9x10² and 4.2x10³ CFU/gm, meanwhile the prevalence of E.coli in the examined packed frozen rabbit samples was 10, 10, 15 and 20% with mean values of 3.0x10², 2.8x10², 5.2x10² and 2.1x10³ CFU/gm in muscles, liver, lungs and kidneys respectively. The heart samples were found to be free from E. coli in both fresh and frozen samples. A total of 40 isolates recovered from fresh rabbit samples were identified to Serovars O55(20%), O26(15%), O127(12.5%), O119(30%), and O111(20%), meanwhile     E. coli belonging to Serovars O146(10%), O55(23.3%), O26(6.7), O127(13.3%), O119(20%) and O111(26.7%) which constituted 30 isolates were recovered from frozen samples. The majority of E.coli serotypes recovered from the examined samples showed hemolytic activity. Public health significant of the isolated serogroups and sanitary control of rabbit meat and edible offals for consumer safety were discussed.