Purpose – This study explored the impact of organizational resilience on Job stress, and the moderating effect of experience on this relationship during the COVID- 19 pandemic in Egypt. Therefore, the main question, which this study tries to answer is:   Does organizational resilience have a significant impact on Job stress during the COVID- 19 pandemic in Egypt? Design/methodology/ approach – This study used both descriptive and field analytical techniques. On the one hand, the researcher used descriptive techniques to review and evaluate the literature. On the other hand, the researcher used analytical techniques to analyze the data, obtained from the targeted sectors, about the moderating effect of experience on organizational resilience's impact on Job stress. Consequently, this study was able to achieve its purpose of assessing the impact of organizational resilience dimensions on Job stress and the moderating role of experience in Egypt during the COVID- 19 pandemic. Based on a simple sampling method, the researcher distributed 300 questionnaires in the Egyptian market and, once incomplete questionnaires were excluded, the researcher collected 231 usable samples. This represented a 77% response rate, which was for those who willingly participated. Findings- The data analysis reveals that uncertainty about the future is the most important dimension of organizational resilience and that its reduction had a positive effect on Job stress. The study findings show that the greater the amount of experience, the less the effect of uncertainty, livelihood, and governance.  In addition, when there are high levels of experience, there is a reduction in the impact of threats and other stresses on Job stress. Practical implications – One of the main findings of this study is that organizations must pay more attention to organizational resilience by creating a special resilience framework that relies on aspects of future uncertainty, threats and stresses, livelihood, and governance. Also, Job stress can be enhanced by focusing on the control of organizational resilience.