Pleurotus ostreatus and Phanerochaete chrysosporium successfully to upgrade nutritional value of wheat straw in combined mixture with artichoke petals at different ratios (1:1, 1:3 and 3:1), using solid state fermentation technique. Treatment with Pleurotus ostreatus succeeded to increase protein content of wheat straw from 3.30% to 10.85 when it was mixed with artichoke petals at ratio of 1:1 and fermented for 30 days,While Phanerochaete chrysosporium increased crude protein content of wheat straw to 11.10%. Pronounced degradation of hemicellulose and lignin was recorded, when wheat straw was mixed with artichoke petals at different ratios (1:1, 1:3 and 3:1). In addition, treatment of wheat straw white rot fungi improved in vitro digestibility when artichoke petals were added. The present study indicated that fungal treatment of wheat straw when mixed with artichoke petals improved the nutritive value and digestibility of poor quality roughages and produced a nutritionally valuable feed replacing good quality roughage for ruminants.Further studies are recommended to test the digestibility coefficients of the treated materials through metabolism trials.Also feed trial is needed to estimate their trend on platability; feed intake, live body gain, feed conversion and economic efficiency.