TILL now there is no way to avoid human being exposed to harmful chemicals and heavy metals in urban and industrial world. The aim of this experiment was to find out the negative effect of Lead (Pb), Cadmium (Cd) and Mercury (Hg) on hepatic cells and how date fruit could reduce their effects in vetro, as well as, evaluate the Balady bread produced by adding different ratios of date powder (0, 0.25, 0.50 and 1%). Results clearly showed that, the most effective tested dose of ethanolic date fruit powder extract against tested heavy metals (Pb, Cd, and Hg) was 400 μg/mL. This dose recorded a hepato-protective effect of 32.12±4.19 % for Lead, 22.49±3.88 % for Cadmium and 18.77±2.62% for Mercury, respectively. Also, it improved the cellular viability of cultured liver cells to 53.03±4.53, 37.67±2.84 and 27.86±4.21 %, for Pb, Cd, and Hg, respectively. On the other side, addition of date powder to Balady bread had no significant effect (p > 0,05) on chemical composition of the produced bread with one exception related to polyphenol content which increased significantly (p < 0.05). Also, two date powder ratios (0.5 and 1%) had positive effects on all sensory properties. The obtained results suggested that, date powder could be considerable solution in reduction of heavy metal hepato-toxicity and applicable in Balady bread.