Sixty six random samples of fast food sandwiches, each about 200 g were randomly collected from Fayoum, Egypt. Eleven sandwiches of liver, burger, sausage, chicken shawarma,meat shawarma and chicken crepe were purchased from different shops and markets. The samples were subjected to microbiological examination. The highest mean mesophilic count was 2.36x1010 CFU/g in chicken shawarma sandwiches samples, while the highest mean count of Entero bacteriaceae count was 4.69x106 CFU/g in burger sandwiches samples. Enterobacter cloacae is the most isolated Enterobacteriaceae species in sandwiches of burger, meat shawarma, sausage, and liver in a percentage of 69%,44%,42% and 33%, respectively. The percentage of CPS and TN asepositive strains of Staphylococci isolated from examined sandwiches ofliver, burger, sausage, chicken shawarma,meat shawarmaand chicken crepe were 0.53%, 1.61%, 0.53%, 0.53%, 1.07% and 0.53%, respectively. Salmonella and E.coli could be detected in liver sandwiches samples only with a percentage of 12% and 4%, respectively.