Patients with chronic kidney disease belong to the group of patients with a high prevalence of cardiovascular disease. Atherosclerosis is a common cause of cardiovascular morbidity in patients with chronic kidney disease. Anomalies of left ventricular (LV) structure and function are very frequent too among CKD patients, and show a negative impact on cardiovascular prognosis. The aim of our study was to investigate the prevalence of atherosclerosis and its relation to left ventricular hypertrophy and left ventricular function in patients with CRF. To achieve this target, 50 patients with CKD (20 patients on regular hemodialysis and 30 patients not on dialysis) were recruited to participate in the study, in addition, 20 healthy subjects as a control group matched by age and sex. All subjects incorporated in the study were examined thoroughly and investigated for routine laboratory values. Carotid and femoral ultrasonography was performed to determine CCA IMT, CFA IMT, SFA PWT and presence of carotid plaque. Echocardiography was performed to determine left ventricular hypertrophy and left ventricular systolic and diastolic function.