Background: Caries prevention is better than cure especially in patients with disabilities to avoid the problems associated with the disease & the need for operative treatment. Bacteriotherapy in the form of probiotic bacteria is a promising concept, especially in childhood. The aim of the study was to evaluate the effect of different probiotic strains added to dairy product on salivary Mutans Streptococcus count in a group of children with special health care needs. Methods: Sixty cerebral palsied children, 3 to 6 years old were enrolled in three groups all are following oral hygiene measures; one group used fermented milk containing probiotics, another one used full cream pasteurized cow milk & and the third group oral hygiene only for two weeks. Oral examination was performed before and after the study and after a 2 weeks post-treatment period; dental caries experience and oral hygiene status, and counts of salivary Streptococcus mutans. Results: On statistical evaluation, it was seen that probiotic milk brought about non-statistically significant reduction (p-value ≤ 0.005) in salivary mutans streptococci levels. While with cow milk brought about non-statistically significant increase (p-value ≤ 0.005) in salivary mutans streptococci levels. Conclusion: Fermented milk containing probiotics may be more beneficial to cerebral palsied patients than cow’s milk.