Objective: is to evaluate and compare the accuracy of implant placement after implant surgery with a surgical guide constructed on a 3D printed model from cone beam computed tomography data. Methods: Ten partially edentulous patients were selected for this study and were radiographed using cone beam computed tomography (CBCT). Virtual implant planning was performed on a three dimensional (3D) printed model using a 3D printer A surgical guide was fabricated by adaptation of a prefabricated vacuum stent on the patient's cast on the 3D printed model with the planned implant sites to be used as a surgical guide. After implant placement using the surgical guide, the patients were radiographed using CBCT. Both, the preoperative virtual planning on CBCT was superimposed on the post-operative CBCT image with real implants placed to evaluate accuracy of implant position using linear and angular measurements. Results: There was no statistically significant difference between the deviation of both, linear and angular measurements between the virtual implants and the surgically placed implants. Coclusion: Implant placement with a surgical guide constructed on a 3D printed model from cone beam computed tomography data was accurate.