The major challenges in the slaughter of animals are the need to identify, understand, and develop effective methods and controls against the total losses plaguing Egyptian animal wealth. During three years of study, a total of 8028 slaughtered animals, of which 3587, 3462, 439, and 540 were cows, buffaloes, sheep, and goats, respectively, were slaughtered at the Al-Arish abattoir. The total numbers of organs and carcasses condemned were 248, 212, 212,150, and 105 of cows, buffaloes, sheep, and goats, respectively. The most affected organs in slaughtered cows, buffaloes, sheep, and goats were the lung with 72 (29.0%), 80 (37.7%), 55 (36.7%), and 50 (47.6%); the liver with 30 (12.1%), 40 (18.9%), 50 (33.3%), and 10 (9.5%), respectively; and the esophagus with 30 (12.1%), 30 (14.2%), 20 (13.3%), and 20 (19.1%), respectively. Meanwhile, carcasses with ill bleeding and/or emaciation were 10 (4.0%), 13 (6.1%), 10 (6.7%), and 10 (9.5%), respectively. The major cause of condemnation in all slaughtered animals was pneumonia, with 65 (26.2%), 60 (28.30%), 40 (26.7%), and 40 (38.1%), respectively. Abscess was detected in 20 (8.06%), 30 (14.15%), 30 (20.0%), and 10 (9.5%), respectively. Meanwhile, Sarcocystis occurs with 10 (4.03%), 30 (14.15%), 20 (13.3%), and 20 (19.1%), respectively. Other causes of condemnation in some animal species and not others were liver cirrhosis in cows, buffaloes, and sheep (4.3%, 14.15%, and 13.3%); TB in cows and buffaloes (8.87% and 1.89%); caseous lymphadenitis in sheep and goats; hydatid cysts in sheep and goats; cysticercus bovis in cows; emaciation; ill bleeding; brucella; and jaundice, which were detected with various percentages. The economic losses reached 3781401 LE in cows, 2643160 LE in buffaloes, 60830 / LE in sheep and 94200 / LE in goats with total economic loss reaching 6579591/LE.