Despite the growing interest in hotel performance determinants, there remains a gap in the literature concerning the role of organizational agility, corporate social responsibility, and psychological empowerment as key antecedents in the Egyptian hospitality sector. Therefore, the current research aims to investigate the impact of organizational agility, corporate social responsibility, and psychological empowerment on hotel performance in Egypt. Additionally, the research developed and empirically tested a conceptual model grounded in Stakeholder Theory within the Egyptian hospitality industry. To achieve this objective, web-based questionnaires were distributed to a stratified random sample of 306 employees, supervisors, department managers, and general managers working in Egyptian hotels. The research contributes to the Stakeholder Theory paradigm by experimentally investigating the influence of corporate social responsibility on hotel performance in Egypt. The results declared that organizational agility, corporate social responsibility, and psychological empowerment positively impact the model outcome (hotel performance). Furthermore, the results revealed that organizational agility has the strongest effect among the adopted variables. This research addresses a critical knowledge gap and provides valuable managerial insights for improving hotel performance in the Egyptian hospitality sector.