Workers in petrol stations are often at the forefront of exposure to environmental hazards, including lead pollution. Their perception of lead pollution is shaped by a combination of personal experiences, workplace education, and awareness of health risks. Aim: This study aimed to assess perception of workers regarding lead pollution in petrol stations. Research design: A descriptive exploratory research design was used to conduct the study. Setting: Petrol stations in Atfih center/ El- Giza governorate. Sample: Convenient sample equal about 100 workers. Tools of data collection: Two tools included four parts, 1st part: Demographic characteristics, 2nd part: Medical history, 3rd part: Worker's knowledge assessment questionnaire, 4th part: Attitude of workers regarding lead pollution, and 2nd tool: Observational checklist of workers' practice regarding prevention of occupational hazards from lead pollution. Results: 55.0 % of the studied worker had poor knowledge. While, 60.0 % of the studied workers had negative attitude regarding lead pollution and 55 % of them had unsatisfactory total practices regarding the prevention of occupational hazards from lead pollution. Conclusion: Less than one third of the studied workers had average total knowledge, and less than half of them had positive attitude. While, less than half of them had a satisfactory level in total practices regarding prevention of occupational hazards from lead pollution. Recommendations: Provide health education program for workers about prevention of occupational hazards from lead pollution to improve their condition.