Since ancient times, plants have played a vital role in improving mankind and are an excellent source of natural medicines. The difficulty of formulating chemical drugs, their side effects on health, and rising costs have led researchers worldwide to focus on studying medicinal plants. So, the present study aimed to evaluate the effect of amla and cornsilk against gentamicin-induced nephrotoxicity in experimental rats. Thirty male Albino rats were used, and biological, biochemical, oxidative stress and pathological parameters were evaluated. Results showed that the total phenolic values are significantly higher in amla fruit than corn silk, but it is significantly higher in total flavonoid content than amla fruit. Also, they showed excellent antioxidant activity. GM evoked significant alterations in liver and kidney function biomarkers and biological evaluation. Furthermore, elevations in malondialdehyde (MDA) levels and reduction in reduced glutathione (GSH) activity. However, amla fruit and corn silk could mitigate the GM-inflicted liver and kidney damage, this enhancement was also seen in histopathological examination. In conclusion, amla fruit and byproduct cornsilk can be used for the prevention and treatment of hepatotoxicity and nephrotoxicity.