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419978

EFRE IVF 40; AI model for personalized PGTA decision in women Over 40

Article

Last updated: 09 Apr 2025

OverviewSimilar Items

Subjects

-

Tags

Assisted reproduction

Abstract

Background:
Female fertility declines sharply after 40 due to diminished ovarian reserve, compromised oocyte quality, and a significant increase in aneuploidy rates. In vitro fertilization (IVF) strategies, including repeated cycles, embryo pooling, and preimplantation genetic testing for aneuploidy (PGT-A), present complex decision-making challenges requiring personalized, data-driven approaches.
Objective:
This study aims to develop and evaluate AI-driven predictive models using Meta AI to optimize fertility treatment strategies in women over 40, assisting in selecting between repeated IVF cycles and embryo pooling with PGT-A.
Methods:
A generative AI model (Llama 3.2) was employed to extract and synthesize data from peer-reviewed literature. Expert systems were integrated to formulate a structured decision-support framework, leveraging a knowledge base and inference engine. Two predictive models were developed:
1. Pre-Treatment Evaluation Score (PTES) – Assesses overall fertility potential.
2. Embryo Quality Refinement Score (EQRS) – Incorporates embryo-specific factors to refine treatment recommendations.
Results:
Both models demonstrated high predictive accuracy and clinical relevance. Higher scores indicated a preference for embryo pooling with PGT-A, while lower scores supported repeated IVF cycles. Performance metrics, including precision and AUC-ROC, confirmed the models' efficacy in predicting live birth probability.
Conclusion:
AI-driven predictive modeling offers a novel, data-supported approach to personalized fertility care. These models facilitate evidence-based decision-making, potentially improving clinical outcomes. Further validation in real-world clinical settings is warranted.

DOI

10.21608/jrme.2025.370139.1037

Keywords

AI-driven predictive modeling, advanced maternal age, embryo pooling, embryo accumulation, PGTa

Authors

First Name

Hassan

Last Name

Maghraby

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

hassanmaghraby@gmail.com

City

-

Orcid

0000-0003-3661-1594

First Name

Mohamed

Last Name

Elmahdy

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

mahdy_moh@yahoo.com

City

-

Orcid

0000-0003-4332-9845

First Name

Sherif

Last Name

Gaafar

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt., Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

shgaafar301@yahoo.com

City

-

Orcid

-

First Name

Ashraf

Last Name

Aboali

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

aboalimadina@yahoo.com

City

-

Orcid

-

First Name

Nehal

Last Name

Adel

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Madina Fertility Center, Madina Women's Hospital, Alexandria, Egypt.

Email

nehal_adel83@hotmail.com

City

Alexandria

Orcid

0000-0002-2853-8334

First Name

Yasser

Last Name

ElKassar

MiddleName

-

Affiliation

Obstetrics and Gynecology Department, Faculty of Medicine, Alexandria University, Egypt. , Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt.

Email

yasser_elkassar@hotmail.com

City

-

Orcid

-

First Name

Heba

Last Name

Hassan

MiddleName

-

Affiliation

Egyptian Foundation of Reproductive Medicine and Embryology (EFRE), Egypt., Dar Alteb Infertility Center, Alexandria, Egypt.

Email

hebahali85@gmail.com

City

-

Orcid

-

Volume

1

Article Issue

4

Related Issue

54794

Issue Date

2025-02-01

Receive Date

2025-03-21

Publish Date

2025-02-01

Page Start

286

Page End

297

Online ISSN

3009-7282

Article File

JRME_Volume 1_Issue 4_Pages 286-297.pdf

PDF . 385.2kB

Link

https://jrme.journals.ekb.eg/article_419978.html

Detail API

http://journals.ekb.eg?_action=service&article_code=419978

Order

11

Type

Original Article

Type Code

2,940

Publication Type

Journal

Publication Title

Journal of Reproductive Medicine and Embryology

Publication Link

https://jrme.journals.ekb.eg/

MainTitle

EFRE IVF 40; AI model for personalized PGTA decision in women Over 40

Details

Type

Article

Created At

09 Apr 2025