417779

Antifungal susceptibility patterns of vulvovaginal Candida species among Pregnant and Non Pregnant Women

Article

Last updated: 29 Mar 2025

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Tags

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Abstract

Objectives: Determination of different Candida species present in vagina of pregnant and non-pregnant women with recurrent vaginal candidiasis, and the susceptibility patterns of vaginal Candida to antifungal drugs.   
Patients & Methods: This study included 93 women with recurrent clear clinical picture of Candida vaginitis. Divided equally into 3 groups: 31 pregnant women in the third trimester, 31 non-pregnant women in the period of fertility using combined pills and 31 non-pregnant women not using contraception. Two high vaginal swabs were taken by sterile cotton wool swabs soaked in sterile saline. One swab was examined by Gram stain and the second swab was streaked onto a plate of sabouraud dextrose agar (SDA) with chloramphenicol. Identified Candida species were tested for susceptibility to antifungal drugs (Fluconazole, Itraconazole, Caspofungin, Voriconazole, Econazole and Nystatin) by disc diffusion method.   
Results: In this study, Candida albicans and Candida glabrata were the most common species isolated from vaginal specimen followed by Candida krusei. There was a statistically significant increase in the percentage of Candida krusei among non-pregnant not using oral contraception group than other groups. The resistance to Econazole, fluconazol and Itraconazole were significantly increased in C. non albicans more than their resistance in C.albicans.
Conclusion:  Although Candida albicans was the most prevalent species causing vaginal candidiasis in pregnant and non-pregnant using contraception women, candida non albicans are also incriminated in high percentage, e.g. C.glabrata, and C. krusei. Both C. albicans and C. non albicans were highly sensitive to voriconazole and Caspofungin in contrast to other drugs tested.

DOI

10.21608/egyfs.2025.417779

Keywords

Candida, antifungal drugs, susceptibility, Vulvovaginal candidiasis

Authors

First Name

Omar

Last Name

Naser

MiddleName

K.

Affiliation

Department of Obstetrics and Gynecology, Benha university

Email

omarkhaled@fmed.bu.edu.eg

City

Banha

Orcid

0000-0002-5653-7865

First Name

Ahmed

Last Name

Abbas

MiddleName

K.

Affiliation

Department of Obstetrics and Gynecology, Benha faculty of medicine, Benha University, Egypt.

Email

bmr90@hotmail.com

City

-

Orcid

-

First Name

Ali

Last Name

Bendary

MiddleName

A.

Affiliation

Department of Obstetrics and Gynecology, Benha faculty of medicine, Benha University, Egypt.

Email

abendary@yahoo.com

City

-

Orcid

-

Volume

29

Article Issue

2

Related Issue

54518

Issue Date

2025-03-01

Receive Date

2025-03-16

Publish Date

2025-03-01

Page Start

120

Page End

129

Print ISSN

1110-6352

Online ISSN

2536-9768

Link

https://egyfs.journals.ekb.eg/article_417779.html

Detail API

http://journals.ekb.eg?_action=service&article_code=417779

Order

417,779

Type

Original Article

Type Code

319

Publication Type

Journal

Publication Title

The Egyptian Journal of Fertility and Sterility

Publication Link

https://egyfs.journals.ekb.eg/

MainTitle

Antifungal susceptibility patterns of vulvovaginal Candida species among Pregnant and Non Pregnant Women

Details

Type

Article

Created At

29 Mar 2025