This research paper investigates the significance of implementing climate-responsive streetscapes in Cairo's neighbourhoods, with a specific focus on Botros Ghaly Street. Cairo, a city characterized by its hot desert climate, faces numerous challenges related to urban heat islands, poor air quality, and inadequate green spaces. This study aims to highlight the potential benefits of climate-responsive streetscapes in mitigating these issues and enhancing the overall urban environment. The case study focuses on the design and implementation of a climate-responsive streetscape in Botros Ghaly Street, highlighting how urban infrastructure can adapt to local climate conditions. The methodology involves a combination of field observations, surveys, and interviews with residents and urban planning experts, with the use of simulation software such as Autodesk Forma. By using sustainable design and innovative technologies, the project aims to improve thermal comfort, reduce the heat island effect, and create pedestrian-friendly spaces. Botros Ghaly Street, known for its high pedestrian traffic and multifunctional uses, is a suitable site due to its extensive asphalt and concrete, which contribute to urban heat. The study explores the impact of climate-responsive designs on pedestrian behaviour and comfort. The case study of Botros Ghaly Street serves as a model for other neighbourhoods in Cairo, demonstrating the feasibility and advantages of adopting climate-responsive strategies in urban planning. The research concludes with policy recommendations and design guidelines to promote the widespread implementation of climate-responsive streetscapes in Cairo, ultimately contributing to a more resilient and liveable urban environment.