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377731

Novel Pyrazole-Linked Pyran Hybrids: Synthesis, Anti-inflammatory Evaluation, Molecular Docking Studies

Article

Last updated: 29 Mar 2025

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Subjects

-

Tags

Organic chemistry

Abstract

In this study, a series of novel pyrazole-linked pyran hybrids was synthesized starting from 4-acetyl-1,3-diphenyl-1H-pyrazole-5(4H)-ole 1. Their structures were characterized by means of spectroscopic techniques. Further, their anti-inflammatory activities were in vitro examined using inhibition of protein denaturation, membrane stabilization assay, and quantitative real-time PCR (qRT-PCR). Compound 6 showed observed anti-inflammatory activity compared with diclofenac. Moreover, the molecular docking approach for the newly prepared hybrid molecules was also performed against phosphodiesterase 4 enzyme (PDE4) to investigate their binding modes of action. Remarkably, compound 6 exhibited the lowest binding energy (-10.8 kcal/mol) against the target. Additionally, the predicted ADMET properties of these molecules exhibited favorable drug-likeness properties.

DOI

10.21608/ejchem.2024.305934.10053

Keywords

pyrazole-linked pyran, spectroscopic techniques, anti-inflammatory evaluation, PDE4 enzyme, Molecular docking

Authors

First Name

Mohamed

Last Name

Abdelreheim

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Arish University

Email

m_abdelreheim@aru.edu.eg

City

Arish

Orcid

-

First Name

Hend

Last Name

Abdel Rady

MiddleName

S.

Affiliation

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Email

hend.saad@sci.aru.edu.eg

City

Arish

Orcid

-

First Name

Omina

Last Name

Mohamed

MiddleName

A.

Affiliation

Department of Biochemistry and Molecular Biology, Theodor Bilharz Research Institute, Giza, Egypt

Email

oali19871987@gmail.com

City

Giza

Orcid

-

First Name

ibrahim

Last Name

abdelhafiz

MiddleName

saad

Affiliation

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Email

ibrahim.saad@sci.aru.edu.eg

City

Al-arish

Orcid

-

First Name

hala

Last Name

Reffat

MiddleName

M.

Affiliation

Department of Chemistry, Faculty of Science, Arish University, Arish 45511, Egypt

Email

halarefat@aru.edu.eg

City

Arish

Orcid

-

First Name

Aboubakr

Last Name

Abdelmonsef

MiddleName

H.

Affiliation

Chemistry Department, Faculty of Science, South Valley University, 83523 Qena, Egypt

Email

aboubakr.ahmed@sci.svu.edu.eg

City

Qena

Orcid

0000-0002-4616-0224

Volume

68

Article Issue

4

Related Issue

53790

Issue Date

2025-04-01

Receive Date

2024-07-20

Publish Date

2025-04-01

Page Start

167

Page End

176

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 4_Pages 167-176.pdf

PDF . 890.6kB

Link

https://ejchem.journals.ekb.eg/article_377731.html

Detail API

http://journals.ekb.eg?_action=service&article_code=377731

Order

377,731

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Novel Pyrazole-Linked Pyran Hybrids: Synthesis, Anti-inflammatory Evaluation, Molecular Docking Studies

Details

Type

Article

Created At

29 Mar 2025