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368481

Facile one-pot strategy for brain imaging using radiolabeled [99mTc]-tricarbonyl histamine complex in Mice.

Article

Last updated: 09 Mar 2025

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Subjects

-

Tags

Biochemistry

Abstract

This investigation aims to label the histamine ligand, 2-(1H-imidazol-4-yl) ethanamine, using a [99mTc]-tricarbonyl core method for brain imaging. The optimization of all variables and factors influencing the radiochemical reaction is carried out to produce the labeled compound with a high radiochemical yield of 98.5%. The radiolabeled compound was stable for up to 6 hours, with a logarithm of the partition coefficient value at 1.49 ± 0.04. This value suggests the lipophilic characteristics of the [99mTc]-tricarbonyl histamine compound, indicating its potential to cross the blood-brain barrier effectively. The bioevaluation of the radiotracer [99mTc]-tricarbonyl-histamine complex exhibited a notable brain uptake of 8.5% ID/organ at 5 minutes post-injection and, eliminated through the urinary system within 2 hours post-injection. This study explores the promising developments in brain imaging facilitated by the [99mTc]-tricarbonyl histamine complex.

DOI

10.21608/ejchem.2024.283339.9602

Keywords

Histamine ligand, Radiolabeled, [99mTc]-tricarbonyl core, bioevaluation, Brain Imaging

Authors

First Name

M.H.

Last Name

Sanad

MiddleName

-

Affiliation

Labeled Compound Department, Hot Laboratory Centre, Egyptian Atomic Energy Authority, P.O. Box 13755, Cairo, Egypt

Email

drsanad74@gmail.com

City

Qalyobia

Orcid

https://orcid.org/00

First Name

H. M.

Last Name

Eyssa

MiddleName

-

Affiliation

Radiation Chemistry Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy, Authority, P.O. Box 11787, Cairo, Egypt.

Email

norhakeim@gmail.com

City

Qalyobia

Orcid

-

First Name

Safaa B.

Last Name

Challan

MiddleName

-

Affiliation

Labeled Compound Department, Hot Laboratory Centre, Egyptian Atomic Energy Authority, P.O. Box 13755, Cairo, Egypt

Email

safaabekheet@yahoo.com

City

cairo

Orcid

https://orcid.org/00

First Name

A. B.

Last Name

Farag

MiddleName

-

Affiliation

Pharmaceutical Chemistry Department, Faculty of Pharmacy, Ahram Canadian University, Giza, 12578 Egypt.

Email

abfarag81@yahoo.com

City

cairo

Orcid

-

First Name

Fatma Y.

Last Name

Abdou

MiddleName

-

Affiliation

Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy, Authority, P.O. Box 11787, Cairo, Egypt.

Email

fatmayehia2007@yahoo.com

City

cairo

Orcid

-

First Name

Aiten M.

Last Name

Soliman

MiddleName

-

Affiliation

Drug Radiation Research Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy, Authority, P.O. Box 11787, Cairo, Egypt.

Email

aiten.mohamed@yahoo.com

City

cairo

Orcid

-

First Name

S. M.

Last Name

Abd-Elhaliem

MiddleName

-

Affiliation

Labeled Compound Department, Hot Laboratory Centre, Egyptian Atomic Energy Authority, P.O. Box 13755, Cairo, Egypt

Email

sayedabdelhalim488@gmail.com

City

cairo

Orcid

-

First Name

Nermeen M.

Last Name

El Bakary

MiddleName

-

Affiliation

Radiation Biology Department, National Centre for Radiation Research and Technology, Egyptian Atomic Energy Authority, P.O. Box 11787, Cairo, Egypt.

Email

bekheetsfsf@gmail.com

City

cairo

Orcid

-

Volume

68

Article Issue

3

Related Issue

53789

Issue Date

2025-03-01

Receive Date

2024-04-17

Publish Date

2025-03-01

Page Start

37

Page End

50

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 3_Pages 37-50.pdf

PDF . 799.3kB

Link

https://ejchem.journals.ekb.eg/article_368481.html

Detail API

http://journals.ekb.eg?_action=service&article_code=368481

Order

368,481

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Facile one-pot strategy for brain imaging using radiolabeled [99mTc]-tricarbonyl histamine complex in Mice.

Details

Type

Article

Created At

15 Feb 2025