The study aims to determine the effects of natural dietary supplements on endurance performance for weightlifter athletes, therefor, prepared capsule consisting of blended ratio from the powders of probiotics, wheat germ, dandelion, ginseng root, moringa seeds, taurine, spirulina, fenugreek sprout, carob fruit, doum fruit, buckthorn fruit, whey protein isolate and date pits, that are taken orally in capsule form by weightlifting athletes participated in this study for six weeks, male (n= 11) and female (n= 14). The prepared capsule examined for proximate analyses, polyphenols content, amino acids composition and antioxidant status. Also, some anthropometric measurements for male and female athletes were determined. Furthermore, snatch and clean and jerk performances of the athletes were recorded. The results showed that, the suggested dietary supplement capsule had the highest antioxidant activity (116.97 µmole Trolox/g), as well as significant increases in total flavonoid and phenolic content (17.0 mg QUE/g and 25.65 mg GAE/g) and total chlorophyll (2.07 mg/g). Moreover, the dietary supplement capsule consists of a mixture of a wide range of important phenolic compounds. Besides, the composition of amino acids revealed high content from branched-chain amino acids (BCAAs) in the dietary capsule. On the other hand, anthropometric measurements showed that males had greater weight and height than females, also, male was significantly more circumferential around the waist and upper arms than females; in additional, male who lifted weights had significantly larger muscles than females; both genders lifted more weight over the course of six weeks; and male were significantly more efficient at lifting heavier weights than females through snatch and clean and jerk performances. Thus, the results indicated that by incorporating natural dietary supplement powders in the suggested capsule, it is possible to enhance the performance of weightlifter athletes.