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363257

Antiaging and Skin Whitening Potentials of a Galloyl quinic Acid Derivative From Guiera senegalensis (J. F. Gmel.) Bark Extract: A Comparative In Vitro Investigation and Chemical

Article

Last updated: 15 Feb 2025

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Subjects

-

Tags

Organic chemistry

Abstract

Aqueous alcoholic extracts from three different extraction procedures for Guiera senegalensis bark were analyzed both qualitatively for their chemical fingerprints using HPLC and quantitatively for their phenolic content using folin ciocalteu assay. A comprehensive phytochemical study was done on the extract with the largest phenolic content where five phenolic compounds were isolated and identified using conventional chemical methods and advanced spectroscopic techniques; the major compound (4) was identified as 3,4,5-tri-O-galloylquinic acid (UV, 1H-NMR and 13C-NMR). The extracts together with the major phenolic metabolite were subjected to an in vitro biochemical study for their enzyme inhibitory activities which confirmed the pure compound's potential as a promising antiaging and skin whitening agent against tyrosinase (IC50 256 µg/ml), collagenase (IC50 385.6 µg/ml) and elastase (IC50 147.7 ug/ml)

DOI

10.21608/ejchem.2024.294859.9798

Keywords

Guiera senegalensis, Phenolics, galloyl quinic acids, Extraction techniques, Tyrosinase, elastase, collagenase

Authors

First Name

Reham T.

Last Name

El-Sharawy

MiddleName

-

Affiliation

Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St., Former ElTahrir St., P.O.12622, Dokki, Giza, Egypt.

Email

reham_elsharawy@hotmail.com

City

-

Orcid

0000-0003-2926-5283

First Name

Heba D.

Last Name

Hassanein

MiddleName

-

Affiliation

Chemistry of Medicinal Plants Department, National Research Centre, 33 El-Bohouth St., Former ElTahrir St., P.O.12622, Dokki, Giza, Egypt.

Email

-

City

-

Orcid

-

First Name

Rasha A.

Last Name

Radwan

MiddleName

-

Affiliation

Biochemistry Department, Faculty of Biotechnology, German International University, Regional Ring Rd, East Cairo, New Administrative Capital, Egypt.

Email

-

City

-

Orcid

-

First Name

Eman M.

Last Name

El-Taher

MiddleName

-

Affiliation

Department of Pharmacognosy, Faculty of Pharmacy, Egyptian Russian University, P.O. 63514, Badr City, Cairo, Egypt

Email

-

City

-

Orcid

-

First Name

Mona E. S.

Last Name

Kassem

MiddleName

-

Affiliation

Phytochemistry and Plant Systematics Department, National Research Centre, 33 El-Bohouth St., Former ElTahrir St., P.O.12622, Dokki, Giza, Egypt.

Email

-

City

-

Orcid

-

Volume

68

Article Issue

2

Related Issue

53637

Issue Date

2025-02-01

Receive Date

2024-06-03

Publish Date

2025-02-01

Page Start

507

Page End

513

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 68_Issue 2_Pages 507-513.pdf

PDF . 249.1kB

Link

https://ejchem.journals.ekb.eg/article_363257.html

Detail API

http://journals.ekb.eg?_action=service&article_code=363257

Order

363,257

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Antiaging and Skin Whitening Potentials of a Galloyl quinic Acid Derivative From Guiera senegalensis (J. F. Gmel.) Bark Extract: A Comparative In Vitro Investigation and Chemical

Details

Type

Article

Created At

15 Feb 2025