This research is primarily concerned with identifying the applications of human resource information systems (HRIS) in various businesses and their outcomes. This study also aims to provide useful information about the major barriers in the adoption of HRIS to be concerned with. And finally, it describes knowledge acquisition of HRIS and its scope to decide on its extension to SMEs in East African countries. The research findings affirm that optimizing HRIS in MSMEs can improve efficiency, productivity, and organizational performance. Technology-based HRM strategies, such as cloud-based software, mobile applications, and web-based platforms, can streamline HR processes and enhance workforce productivity. The development of MSME's depends heavily on human resource competencies. By optimizing the marketing of products and services, HRIS can support the expansion of MSME's. The study highlights how crucial HRIS optimization is to MSME management. The findings suggest that utilizing technology to support HRIS can improve staff productivity and operational efficiency. It is advised that MSMEs invest in the newest HRIS technology and give their employees the necessary training. These actions will help MSMEs expand and succeed in the contemporary digital environment.