This research mainly aims at exploring the nature of the relationship between human resource Flexibility and Organizational Ambidexterity. The required primary data for this research was obtained through a questionnaire distributed over a sample of 400 managers working in commercial banks in Great Cairo. In order to test research hypotheses, appropriate statistical techniques such as descriptive statistics and multiple correlations and regression analysis had been employed.

The findings of this research revealed that there is a statistically significant positive relationship between human resource flexibility and organizational ambidexterity as a whole, where the most influential human resource flexibility' dimensions on organizational ambidexterity were behavior flexibility, followed by HR practices flexibility. In particular, results indicated that the most influential human resource flexibility' dimensions on exploration were HR practices flexibility, followed by behavior flexibility. Moreover, results showed the most influential human resource flexibility' dimensions on exploitation were behavior flexibility, followed by HR practices flexibility. Finally, based on these results, number of recommendations for managers had been proposed aiming to improve human resource flexibility and organizational ambidexterity in banks under research.