The presented study was carried out at Meddle Egypt (28o 54ʹ N, 30o 56ʹ E) region at Beni-Suef Governorate under clay soil conditions. To Determine the best durum wheat genotypes tolerance to water deficit under Egyptian conditions, Introduce conservation agriculture system (CA) as new technology that reduces using water in durum wheat farms and determine the best genotypes under conservation agriculture system. Therefore, seven durum wheat cultivars are evaluated under four different treatments, yield and yield components traits are recorded. The results indicated that the conservation agriculture systems conserve more soil moisture, and the new system could save more amount of water used in irrigation. The traditional tillage system contributed the highest value in both successive seasons (3.68 and 4.68 kg/plot, respectively) compared to zero- tillage (2.84 and 3.00 kg/plot, respectively). The best durum wheat cultivar under zero-tillage system is Beni-Suef 1 in both growing seasons and both irrigation regime (normal and water deficit), while the best durum wheat cultivars under traditional tillage is Beni-Suef 4 in the first season and Sohage 4 in the second season under normal irrigation and Sohage 5 under water deficit, in spite of traditional system gave the highest value, the consternation agriculture still is best system conserve the consumed water in irrigation, so wheat breeding program 
under conservation agriculture is very important in the future.