The residual levels and degradation behavior of some insecticides (imidacloprid, acetamiprid, clothianidin, pymetrozine, pyriproxyfen, azadirachtin, and spinetoram) in pepper (Capsicum annuum) fruits under greenhouse conditions were determined. The high performance-liquid chromatography with photodiode-array detector "HPLC/ DAD" was used and QuEChERS methodology was followed. The tested insecticides were applied to pepper at the recommended rates. The pepper samples were taken at zero time (1 hour) and after 1, 3, 5, 7, 10, 15, and 21 days post-application. The dissipation half-life time (RL50) of imidacloprid, acetamiprid, clothianidin, pymetrozine, pyriproxyfen, azadirachtin, and spinetoram residues in pepper fruits were 0.239, 1.994, 3.277, 0.151, 7.0233, 2.0285 and 1.251 days, respectively. According to, the maximum residue limit "MRL", the pre-harvest intervals "PHIs" were 3, 5, 7, 1, 10, one hour and 1 day after the application for imidacloprid, acetamiprid, clothianidin, pymetrozine, pyriproxyfen, azadirachtin, and spinetoram, respectively. Results of this study suggest that the dissipation data showed that the, usage of peppers treated with the tested insecticides was safe to consume and prevented health problems from consumers after these intervals.