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350230

New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Organic chemistry

Abstract

Abstract

1,2,4-Triazole-3-thiols have recently garnered sufficient concern due to their cytotoxic and antimicrobial properties, rendering them valuable in aspects of medicine and pharmacology. The interaction of phenyl hydrazine and benzoyl isothiocyanate (1) yielded 1,5-diphenyl-1H-1,2,4-triazole-3-thiol (2), which upon treatment with hydrazine monohydrate after exposure to ethyl-chloroacetate, acetohydrazide (4) was achieved, that was taken into consideration as a raw substance for creating new derivatives (5–9) by interacting with carbon disulfide, isatin, glucose, phthalic anhydride, and various aldehydes. The spectroscopic analysis encompassing (IR, Mass spectrum, 1H-NMR, and 13C-NMR) for those newly synthesized compounds and their behavior against bacteria, fungi, and breast cancer cell lines are covered in this study. Moreover, molecular docking investigation of the antimicrobial action and the structure-activity relationships SAR based on cytotoxic impact are mentioned and discussed.

DOI

10.21608/ejchem.2024.275486.9423

Keywords

Oxadiazole, Schiff-base, Antimicrobial assay, antitumor, Molecular docking

Authors

First Name

Zainab

Last Name

Soliman

MiddleName

Adel

Affiliation

Chemistry Department, Faculty of women for Arts, Science and Education, Ain Shams University

Email

zainab.adel@women.asu.edu.eg

City

Roxy

Orcid

0009-0005-6427-5649

First Name

Emadeldin

Last Name

Kamel

MiddleName

Mohamed

Affiliation

Department of Chemistry, Faculty of Science, Beni-Suef University, Beni-Suef 62514, Egypt.

Email

emad.abdelhameed@science.bsu.edu.eg

City

Beni-Suef

Orcid

-

First Name

Mona

Last Name

Hosny

MiddleName

Amin

Affiliation

Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

Email

monaaminhosny@women.asu.edu.eg

City

Cairo

Orcid

-

First Name

Ahmed F.

Last Name

El Farargy

MiddleName

-

Affiliation

Chemistry Department, Faculty of Science, Zagazig University, Zagazig 44519, Egypt.

Email

aelfarargy@hotmail.com

City

-

Orcid

-

First Name

Wafaa

Last Name

Mokbel

MiddleName

Abd El badi

Affiliation

Department of Chemistry, Faculty of Women for Arts, Science and Education, Ain Shams University, Heliopolis, Cairo 11757, Egypt.

Email

wafaamokbel2017@gmail.com

City

Cairo

Orcid

-

Volume

67

Article Issue

10

Related Issue

49535

Issue Date

2024-10-01

Receive Date

2024-03-08

Publish Date

2024-10-01

Page Start

601

Page End

617

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 10_Pages 601-617.pdf

PDF . 1.4MB

Link

https://ejchem.journals.ekb.eg/article_350230.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=350230

Order

350,230

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

New Design and Synthesis of a Variety of 1,2,4-Triazole Thiol Derivatives: Studying their Antimicrobial and Potential Cytotoxic Effect

Details

Type

Article

Created At

30 Dec 2024