Most of polymers instead of Polyvinyl Chloride (PVC) were degraded by UV or thermal, so most researchers want to solve this problem by modifying these polymers and realizing their importance instability (thermal and photo), bioactivity, and …..etc. The driving force in polymer science is generating novel materials for variable applications. The success of the new materials relies mainly on the ability to be manufactured on a large scale and in high quality. Polyvinyl Chloride (PVC) is one of the famous polymers used by manufacturers all over the world. Therefore, we are going to consider polyvinyl chloride (PVC) as one of the polymers acting as a distinctive material with a vast application domain. Modification of PVC with synthesized heterocyclic derivatives such as pyrazole, imidazole, thiazole, and triazoles enhances its stabilization, bioactivity, and relatively high chemical resistance to be an abundant and affordable cost.As the world and the needs of civilization are changing, new creative ideas for the applications of PVC are continually emerging It is undoubtely one of the most promissing continually improved raw materials of the future.The PVC showed progress upon applying nucleophilic substitution reactions. The biological compatibility of PVC during the surface modification process is important to ensure the effectiveness of the enhanced PVC. The heterocyclicare the nucleophiles that facilitate the structural unit of the synthesized molecules. The chemical heterocycles are bonded to (PVC) forming new molecular adducts with various physical and chemical properties.