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350233

Protective role of fucoxanthin from Dilophys fasciola on the kidneys against the detrimental effect of fast green pigment in albino rats

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Synthetic fast green pigment (FG) is widely used worldwide as a food color for children, and it also promotes oxidative stress, attention deficit, and hyperactivity disorder in mammals. This experiment aims to evaluate oxidative stress and kidney function of rats exposed to Fast Green dye and the protective effects of algal fucoxanthin as an antioxidant and anti-inflammatory. Fucoxanthin was identified by HPLC. Antioxidant activity was determined by ferrous chelating and reducing power activities assays. Fucoxanthin showed potent antioxidant activity against Fe2+ chelating (IC50= ​​820.48 ± 1.79 μg/ml ) and reducing power (EC50 37.3± 1.09 μg/ml). Fast green dye treatment resulted in significant renal insufficiency in rats after 28 days of treatment. This was demonstrated by elevated kidney levels of albumin, creatinine, urea, tumor necrosis factor-alpha (TNF-α), and lipid peroxidation. It's interesting to note that urea, creatinine, lipid peroxidation, and tumor necrosis factor-alpha (TNF-α) levels all dramatically dropped in rats given algal fucoxanthin treatment. This demonstrates that fucoxanthin is essential in preventing kidney damage while undergoing therapy. Our results indicate that fucoxanthin shields rats' kidneys from oxidative damage brought on by the fast green pigment.

DOI

10.21608/ejchem.2024.274249.9405

Keywords

Marine algae, fucoxanthin, synthetic pigment, Kidney function, Oxidative Stress

Authors

First Name

Karem

Last Name

Fouda

MiddleName

-

Affiliation

Nutrition and Food Sciences Department, National Research Centre, 33 El Bohouth St.(former El Tahrir St.), Dokki, Giza, 12622, Egypt.

Email

karemfouda@gmail.com

City

cairo

Orcid

0000-0001-7018-4202

First Name

Walid

Last Name

Abdallah

MiddleName

E.

Affiliation

Chemistry of Medicinal Plants Department,National Research Centre, 33 El Bohouth St.(former El Tahrir St.), Dokki, Giza, 12622, Egypt.

Email

walsay2003@yahoo.com

City

Giza

Orcid

0000-0002-4183-0137

First Name

Rasha

Last Name

Mohamed

MiddleName

S.

Affiliation

Nutrition and Food Sciences Department, National Research Centre, 33 El Bohouth St.(former El Tahrir St.), Dokki, Giza, 12622, Egypt.

Email

smarasha2019@gmail.com

City

-

Orcid

0000-0003-4223-000X

First Name

Alaa

Last Name

Gaafar

MiddleName

A.

Affiliation

Plant Biochemistry Department, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt.

Email

dr.gaafar2308@hotmail.com

City

Cairo

Orcid

0000-0003-4283-8111

First Name

Soha

Last Name

Murad

MiddleName

A.

Affiliation

Plant Biochemistry Department, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt.

Email

sohaahmed77@gmail.com

City

-

Orcid

0000-0001-7649-4391

First Name

Eman

Last Name

Ibrahim

MiddleName

A.

Affiliation

Plant Biochemistry Department, National Research Centre, 33 El Buhouth St., Dokki, Giza, 12622, Egypt.

Email

eman_1975_11@yahoo.com

City

-

Orcid

0000-0002-3120-7667

Volume

67

Article Issue

10

Related Issue

49535

Issue Date

2024-10-01

Receive Date

2024-03-03

Publish Date

2024-10-01

Page Start

405

Page End

411

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 10_Pages 405-411.pdf

PDF . 409.2kB

Link

https://ejchem.journals.ekb.eg/article_350233.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=350233

Order

350,233

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Protective role of fucoxanthin from Dilophys fasciola on the kidneys against the detrimental effect of fast green pigment in albino rats

Details

Type

Article

Created At

30 Dec 2024