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342555

Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

The structural diversity and biological significance of pyrimidine core attracted the attention of many researchers and scientists in the past years owing to their inclusion in the composition of most nucleotides, including DNA and RNA. One unique scaffold was pyrimidine-5-carbonitrile and its importance is largely related to a wide range of biological activities of pyrimidine-5-carbonitrile derivatives such as anticancer, antimicrobial, anti-inflammatory, antifungal, antitubercular, antiviral, antihypertensive, anthelmintic, anticonvulsant, and antimalarial. The key point of this review is to collect and review the most recent and available synthetic pathways for pyrimidine-5-carbonitrile derivatives from different starting materials and focus on the promising derivatives with valuable pharmacological activities.

DOI

10.21608/ejchem.2024.264757.9231

Keywords

Pyrimidine-5-carbonitrile, Biological Activity

Authors

First Name

Nada A.

Last Name

Edris

MiddleName

-

Affiliation

Internal Pharmacist at Banha University Hospitals, Al-Qalyubia, Cairo

Email

nadawedris@gmail.com

City

Al-Qalyubia

Orcid

-

First Name

Hanan H.

Last Name

Kadry

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt.

Email

hanan.kadry@pharma.cu.edu.eg

City

Giza

Orcid

-

First Name

Azza

Last Name

Taher

MiddleName

T.

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt. , Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, October 6 University (O6U), 6th of October City 12585, Egypt, Giza, Egypt

Email

azza.shalaby@pharma.cu.edu.eg

City

Giza

Orcid

-

First Name

Mina E.

Last Name

Adly

MiddleName

-

Affiliation

Department of Pharmaceutical Organic Chemistry, Faculty of pharmacy, Cairo University, Cairo 11562, Egypt.

Email

mina.adly@pharma.cu.edu.eg

City

-

Orcid

-

Volume

67

Article Issue

9

Related Issue

48208

Issue Date

2024-09-01

Receive Date

2024-01-22

Publish Date

2024-09-01

Page Start

439

Page End

462

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 67_Issue 9_Pages 439-462.pdf

PDF . 4.5MB

Link

https://ejchem.journals.ekb.eg/article_342555.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=342555

Order

342,555

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Pyrimidine-5-carbonitriles: A review of available synthetic approaches and biological evaluation for promising compounds over the last decade

Details

Type

Article

Created At

30 Dec 2024