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266073

Hands-on Synthetic Approaches and Biological Activities of Anthranilic Acid Derivatives: A mini-review

Article

Last updated: 01 Jan 2025

OverviewSimilar Items

Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Anthranilic acid scaffold is a pivotal class of amino organic acids used for the construction of many organic candidates exhibiting a wide range of industrial, pharmaceutical, and biological activities. In addition, anthranilic acid derivatives are considered a cheap and efficient stating precursor for the production and synthesis of various marketed available drugs like furosemide (diuretic), tranilast (antiallergic), betrixaban (anticoagulant) and analgesic & anti-inflammatory fenamates. Furthermore, numerous anthranilic acid analogs with potential anticancer, antimicrobial, insecticidal, antiviral, anti-inflammatory activities and other biological activities have been disclosed over the last thirty years. The current review represents a brief and simple summary of different synthetic methodologies and techniques applied for the construction and synthesis of different anthranilic acid analogs and derivatives along with a concise discussion of the potential therapeutic activity of these synthesized derivatives.

DOI

10.21608/ejchem.2022.148409.6426

Keywords

Ullmann-Goldberg, ultrasonic irradiation, Microwave irradiation, Anticancer, Human aldo-keto reductase, HCV-NS5B, nuclear farnesoid x receptor

Authors

First Name

Tamer

Last Name

Nasr

MiddleName

Mohamed

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt. Department of Pharmaceutical Chemistry, Faculty of Pharmacy, MTI University, Cairo, Egypt.

Email

tamerhefni@pharm.helwan.edu.eg

City

cairo

Orcid

-

First Name

Ahmed

Last Name

Aboshanab

MiddleName

Mordy

Affiliation

Pharmaceutical Chemistry department, Faculty of Pharmacy, Helwan University, Cairo, Egypt

Email

ahmed_mordy@pharm.helwan.edu.eg

City

Helwan

Orcid

0000-0003-0334-2834

First Name

Khaled

Last Name

Abouzid

MiddleName

Abouzid Mohamed

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Ain Shams University, Abbassia, Cairo , Egypt Department of Organic and Medicinal Chemistry, Faculty of Pharmacy, University of Sadat City, Sadat City , Egypt

Email

khaled.abouzid@pharma.asu.edu.eg

City

Cairo

Orcid

0000-0001-9851-5624

First Name

Wafaa

Last Name

Zaghary

MiddleName

Abdou

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Helwan University, Helwan, Cairo, Egypt.

Email

wafaa.zaghary@pharm.helwan.edu.eg

City

Cairo

Orcid

-

Volume

66

Article Issue

7

Related Issue

42039

Issue Date

2023-07-01

Receive Date

2022-07-02

Publish Date

2023-07-01

Page Start

329

Page End

343

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 7_Pages 329-343.pdf

PDF . 324.0kB

Link

https://ejchem.journals.ekb.eg/article_266073.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=266073

Order

266,073

Type

Review Articles

Type Code

444

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Hands-on Synthetic Approaches and Biological Activities of Anthranilic Acid Derivatives: A mini-review

Details

Type

Article

Created At

30 Dec 2024