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254573

Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus

Article

Last updated: 01 Jan 2025

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Subjects

-

Tags

Pharmaceutical Chemistry

Abstract

Opuntia ficus peels or Prickly pear peel (PPP) is the waste byproduct obtained during fruit processing, the present study aims to extract polysaccharides from PPP and analyze it by HPLC. The biological potential activities as antioxidant, anti-inflammatory, antiviral, and anti Alzheimer of these polysaccharides were examined. Polysaccharides were extracted from PPP using hot water. Its composition was analyzed by HPLC. Profiles of 14 different natural mono sugars were identified. Stachyose, galactose, xylose, and sucrose were the most abundant sugars. Results indicated that the polysaccharides of PPP extract have antioxidant activity against DPPH and ABTS free radical. The scavenging activity of (150 µg /ml) of polysaccharides appeared to be interesting compared to synthetic antioxidants. Polysaccharides of PPP had 77.77% anti-inflammatory activity which is caused by inhibiting the heat-induced albumin denaturation and anti-Alzheimer effect (42.02%) compared to Donepezil drug (59.50%) in a dose-dependent manner. On the other hand polysaccharides of PPP extract showed no activity when tested against HSV-1 and Influenza A by plaque reduction assay. Thus, it could be suggested that polysaccharides PPP demonstrated potential biological activities as an antioxidant, anti-inflammatory, and anti-Alzheimer activities.

DOI

10.21608/ejchem.2022.148208.6435

Keywords

Opuntia ficus peels, polysaccharides bioactivity, HPLC

Authors

First Name

Soha

Last Name

Murad

MiddleName

Ahmed

Affiliation

Plant Biochemistry Department , Agricultural and Biology Research Institute, National Research Centre, Dokki, Cairo

Email

sohaahmed77@gmail.com

City

-

Orcid

0000-0001-7649-4391

First Name

Dina

Last Name

Abd-Elshafy

MiddleName

N.

Affiliation

Immune and Biomarkers for Infection (CEAS), National Research Centre

Email

dnanadeem@yahoo.com

City

Cairo

Orcid

0000-0002-2777-2487

First Name

Doha

Last Name

Abou Baker

MiddleName

H

Affiliation

Medicinal and Aromatic Plant Department, National Research Centre (NRC), 33 EL Bohouth St. (Former El Tahrir St.), Dokki, Giza, Egypt, P.O.1262.

Email

dohaboubaker@gmail.com

City

Cairo

Orcid

0000-0001-6853-041X

First Name

Mahmoud

Last Name

Bahgat

MiddleName

M.

Affiliation

Therapeutic Chemistry Department, National Research Centre (NRC), 33 EL Bohouth St. (Former El Tahrir St.), Dokki, Giza, Egypt, P.O.1262

Email

mbahgatriad@yahoo.com

City

Cairo

Orcid

0000-0002-6485-8722

First Name

Eman

Last Name

Ibrahim

MiddleName

Ahmed

Affiliation

Plant Biochemistry Department , Agricultural and Biology Research Institute, National Research Centre, Dokki, Cairo

Email

eman_1975_11@yahoo.com

City

Cairo

Orcid

0000-0002-3120-7667

First Name

Alaa

Last Name

Gaafar

MiddleName

Abdallah

Affiliation

Plant Biochemistry Department , Agricultural and Biology Research Institute, National Research Centre, Dokki, Cairo

Email

dr.gaafar2308@hotmail.com

City

Cairo

Orcid

0000-0003-4283-8111

First Name

Zeinab

Last Name

Salama

MiddleName

-

Affiliation

Plant Biochemistry Department , Agricultural and Biology Research Institute, National Research Centre, Dokki, Cairo

Email

dr.zeinabsalama70@gmail.com

City

Cairo

Orcid

0000-0002-5231-2976

Volume

66

Article Issue

5

Related Issue

41550

Issue Date

2023-05-01

Receive Date

2022-07-04

Publish Date

2023-05-01

Page Start

237

Page End

244

Print ISSN

0449-2285

Online ISSN

2357-0245

Article File

EJCHEM_Volume 66_Issue 5_Pages 237-244.pdf

PDF . 420.0kB

Link

https://ejchem.journals.ekb.eg/article_254573.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=254573

Order

254,573

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

Unveiling The Anti-Alzheimer, Antioxidant, Anti-Inflammatory, Antiviral Therapeutic Functionality Of Polysaccharides Extracted From Opuntia Ficus

Details

Type

Article

Created At

30 Dec 2024