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The potential of Fermented Asparagus sprengeri extract by Lactobacillus plantarum DMS 20174 on Antioxidant Properties and Memory Retention in vitro and in vivo.

Article

Last updated: 01 Jan 2025

Subjects

-

Tags

Biochemistry

Abstract

Asparagus sp. are a superior gift from nature to promote a disease-free, healthy lifestyle. Through Gut-Brain Axis contact, Lactobacillus strains perform a therapeutic role in neurodegenerative illnesses, particularly Alzheimer's disease (AD). This study was aimed to determine the effect of asparagus extract on Lactobacillus plantarum DMS 20174 (L. plantarum) resistance to acid, bile salt, gastric and intestinal environments. Also, the impact of fermented asparagus extract on antimicrobial, antioxidant and anti-cholinesterase activities was evaluated. Furthermore, the study aimed to investigate the dietary treatment effect of fermented Asparagus extract on anti-Alzheimer and microbiological properties in high fat diet (HFD) fed albino rats. L. plantarum cells gained some resistance towards harsh gastric and intestinal conditions with asparagus extract. Various short chain fatty acids (SCFA) were detected by HPLC in cell free extract (CFE) of the fermented extract. Its antimicrobial activity, scavenging of DPPH and anti-cholinesterase activity were improved. Treatment of high fat diet (HFD) groups with L. plantarum and asparagus extract decreased acetyl cholinesterase (AChE) and malondialdehyde (MDA). Furthermore, treatment with DMS 20174, asparagus extract, and the combined mixture had greater counts of Lactobacilli and lower counts of total aerobes, coliform bacteria, staphylococci, and fungi with HF-fed mice. In conclusions: fermented asparagus extract may be useful in reducing risk of neurodegenerative diseases.

DOI

10.21608/ejchem.2022.141992.6211

Keywords

fermentation, Asparagus sprengeri, Lactobacillus plantarum, Alzheimer, antioxidants, anticholinesterase activity

Authors

First Name

Ebtehag A.E.

Last Name

Sakr

MiddleName

-

Affiliation

Botany Department, Faculty of Women for Arts, Science and Education, Ain Shams University,

Email

ebtehag.abdelfattah@women.asu.edu.eg

City

-

Orcid

-

First Name

Omar A.

Last Name

Ahmed farid

MiddleName

-

Affiliation

Physiology Department, National Organization for Drug Control and Research (NODCAR).

Email

ebntaimya@yahoo.com

City

-

Orcid

0000-0002-1020-5777

First Name

Maha M.

Last Name

Mohamed

MiddleName

-

Affiliation

Home Economic Department, Faculty of Women for Arts, Science and Education, Ain Shams University.

Email

maha.mahmoud.mohamed@women.asu.edu.eg

City

-

Orcid

0000-0002-6798-8741

Volume

66

Article Issue

2

Related Issue

39241

Issue Date

2023-02-01

Receive Date

2022-05-31

Publish Date

2023-02-01

Page Start

479

Page End

494

Print ISSN

0449-2285

Online ISSN

2357-0245

Link

https://ejchem.journals.ekb.eg/article_241876.html

Detail API

https://ejchem.journals.ekb.eg/service?article_code=241876

Order

241,876

Type

Original Article

Type Code

297

Publication Type

Journal

Publication Title

Egyptian Journal of Chemistry

Publication Link

https://ejchem.journals.ekb.eg/

MainTitle

The potential of Fermented Asparagus sprengeri extract by Lactobacillus plantarum DMS 20174 on Antioxidant Properties and Memory Retention in vitro and in vivo.

Details

Type

Article

Created At

30 Dec 2024