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312067

Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance

Article

Last updated: 29 Dec 2024

OverviewSimilar Items

Subjects

-

Tags

Chemistry and Biochemistry

Abstract

Cancer treatment has been confronted with serious challenges. These challenges stemmed from the heterogeneity of tumor microenvironment, as well as genetic and epigenetic factors related to cancer cells. The changes imposed by the tumor lead to the development of acquired resistance. Drug efflux, inhibition of apoptosis, immunosuppression are examples of resistance mechanisms imposed by cancer cells. Nanotechnology has sought to overcome these resistance mechanisms through enhanced cellular uptake, activation of alternative pathways by combined drug delivery, or targeting immune cells leading to their activation and proliferation. Several types of nanomedicine-based systems were implemented; however, protein and peptide nanoparticles remain one versatile tool in drug delivery, providing preferable physicochemical and biological implications. Notably, protein and peptide nanocarriers can also exhibit enhanced cellular uptake, the possibility of tuned drug release, and hence, better tumor targetability. Here, we present the methods of fabrication, physicochemical characteristics, biological implications, and future perspectives, focusing on overcoming cancer drug resistance.

DOI

10.21608/ajst.2023.206740.1008

Keywords

proteins, peptides, Nanoparticles, Tumor, cancer drug resistance

Authors

First Name

Mohamed

Last Name

Abdellatif

MiddleName

Khaled

Affiliation

Department of Industrial Pharmacy, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt

Email

mohamed.khaled.abdellatif96@gmail.com

City

-

Orcid

-

First Name

Islam

Last Name

Hassanin

MiddleName

-

Affiliation

Department of Biotechnology, Institute of Graduate Studies and Research (IGSR), Alexandria University, Alexandria, 21526, Egypt.

Email

s-islam.hassanin@alexu.edu.eg

City

Alexandria

Orcid

0000-0003-3045-3572

First Name

Yosra

Last Name

Mahmoud

MiddleName

Saeed

Affiliation

Department of Biotechnology, Institute of Graduate Studies and Research (IGSR), Alexandria University, Alexandria, 21526, Egypt.

Email

yosra.saeed.m@gmail.com

City

-

Orcid

-

First Name

Mohamed

Last Name

Teleb

MiddleName

-

Affiliation

Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Alexandria University, Alexandria, 21521, Egypt

Email

mohamedtelebismail@gmail.com

City

Alexandria

Orcid

-

First Name

Adnan A.

Last Name

Bekhit

MiddleName

-

Affiliation

University of Bahrain, Sakhir, Bahrain

Email

adnbekhit@pharmacy.alexu.edu.eg

City

-

Orcid

-

First Name

Sherine

Last Name

Khattab

MiddleName

N.

Affiliation

Chemistry Department, Faculty of Science, Alexandria University, Egypt

Email

sherinekhattab@alexu.edu.eg

City

alexandria

Orcid

0000-0002-3162-6386

Volume

1

Article Issue

1

Related Issue

43467

Issue Date

2023-06-01

Receive Date

2023-04-19

Publish Date

2023-06-01

Page Start

1

Page End

21

Print ISSN

2974-3265

Online ISSN

2974-3273

Article File

AJST_Volume 1_Issue 1_Pages 1-21.pdf

PDF . 2.2MB

Link

https://ajst.journals.ekb.eg/article_312067.html

Detail API

https://ajst.journals.ekb.eg/service?article_code=312067

Order

312,067

Type

Review Article

Type Code

2,783

Publication Type

Journal

Publication Title

Alexandria Journal of Science and Technology

Publication Link

https://ajst.journals.ekb.eg/

MainTitle

Protein and Peptide-based Nanoparticles as an emerging strategy to tackle cancer drug resistance

Details

Type

Article

Created At

29 Dec 2024