Analysis of Ficus carica L. fruits using electrochemical technique and ultra-high performance liquid chromatography coupled with mass spectrometry (UPLC-MS) was carried out for the first time. The Ficus carica, commonly known as the fig tree, is a perennial fruit-bearing tree native to the Middle East and Western Asia and is considered one of the healthiest dried fruits because of its high mineral and vitamin contents. In the current manuscript, we will recognize and quantify the bioactive compounds that exist in Ficus carica fruits to provide valuable information for their potential therapeutic applications. Voltammetry and UPLC-MS techniques enable the identification and quantification of a wide range of bioactive antioxidant compounds found in complex matrices such as plant extracts. The analysis of Ficus carica fruits using UPLC revealed the presence of several electroactive species such as phenolic acids, flavonoids, and tannins. Interestingly, the SWV showed sensitive and reproducible results compared to the benchmark protocol for assessment of the antioxidant activity.