Nano-technology plays a pivotal role across various fields, particularly in architecture and construction. Leveraging nanotechnology is of utmost importance in improving energy efficiency in buildings. With growing concerns about local energy consumption, particularly electricity, research aims to develop a range of nanomaterials for exterior cladding or therapeutic interiors to enhance thermal performance. This involves studying nanomaterials, their properties, and the impact of nanotechnology on the exterior cladding, especially for hospital buildings. Furthermore, the research focuses on examining a range of models for implementing nanotechnology to illustrate its impact on enhancing the thermal performance of hospital buildings. This includes conducting simulations using design builder software and comparing the thermal performance under normal conditions versus when nanotechnology-infused materials are incorporated. the study demonstrated a 16% reduction in energy consumption in the studied hospital building when nanotechnology was employed in coatings and glass applications. The study concludes by presenting a set of results and recommendations affirming the efficacy of utilizing nanotechnology to improve energy efficiency and thermal performance in buildings