Abstract   Evening primrose seed oil (Oenothera biennis) has many activities including anti-oxidant, and anti-inflammatory. The present study was carried out to investigate the effect of evening primrose seed oil (EPO) in stannous chloride (SnCl₂) intoxicated rats. This study was conducted on twenty four albino male rats and classified into four groups, one of them served as control group while the four groups injected with SnCl₂. Group 2 received only SnCl₂. Groups 3and 4 were administrated 10 and 20 ml/kg/diet/day EPO for 6 weeks.  Results revealed that EPO resulted in a significant decrease in aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, tumor necrosis factor, acetyl cholinesteras, very low density lipoprotein, cholesterol and triglycride, creatinine, urea nitrogen and uric acid values, however caused a significant increase in sexual hormonal levels when compared to the control (+ve), in a dose dependant manner. It can be concluded that treatment with of evening primrose oil increases the protective capacity against toxicity effects of stannous chloride