The objective of the present work was to evaluate the effect of bee venom (BV) on productive performance and immune response of Zaraibi male goats. Fifteen males aged (52 weeks) with average body weight (BW) of 17.87 kg were divided into three groups (5 goats / each). The first treatment (T1) was control group fed on basal diet and injected with 1 m1 of distilled water /male. The second (T2) and third (T3) treatment groups were fed on control diet and injected with 1 ml of 250 or 500 mg/L of BV /male, respectively. The three treated groups were injected intramuscularly two times / week for 4 weeks. The collected data at 2 (W2) and 4 (W4) weeks post BV injection  showed that (T2) and (T3) groups had higher body weight gain (BWG), performance index (PI), production efficiency factor (PEF), lower feed intake (FI) and better feed conversion ratio (FCR) than (T1) group. The (T2) group displays a prominent and higher levels in total protein (TP) and globulin (Glob) than (T1) and (T3) groups at W2 and W4 post injection. Total antioxidant capacity (TAC) and immunoglobulin G (IgG) concentration of (T2) group were significantly more than those of (T1) and (T3) groups at W2 . Lysozyme concentration was significantly higher in (T2) group at W4 than (T1) and (T3) groups. The study concluded that injection of Zaraibi male goats with BV especially 250 mg/L can ameliorate productive performance, and immune response which reverberates positively on economic efficiency.