Bovine mastitis is one of the most harmful diseases in the dairy herds worldwide. The prevalence rate of antimicrobial resistance (AMR) pathogens causing bovine mastitis increased rabidly all over the world causing high economic losses and public health hazard. Therefore, this review summarized the phenotypic and genotypic characterization of AMR in the main pathogens causing mastitis in Egypt and different countries in the world.  Also some plans or recommendation programs to decrease and overcome AMR.