Lumpy skin disease (LSDV) is of significant economic impact for the cattle industry in Africa, Middle East and Egypt. The disease is spreading aggressively posing threats to cattle industry. Due to cross-protection, Neethling and sheep pox virus (SPV) vaccines have been used for cattle against LSDV. In this work, living attenuated Neethling and sheep pox vaccines were used for vaccination of cattle and evaluated under field conditions.14susceptible calves were vaccinated with live attenuated Neethling vaccine and4 cattle were vaccinated with live attenuated sheep pox vaccine with 8cattleas non-vaccinated control (4cattle for each).The humeral immunity was measured by double antigen ELISA while, cellular immune response were evaluated by interferon gamma (IFN-γ) concentration real time PCR. Humeral immune response of cattle vaccinated with SPV vaccine evaluated by ELISA, showed that the immune response begins at 7^thdayPV with absorbance of 1.4 ±0.075 then by the 14^th& 28^thDPV with mean ELISA 2.02 ±0.0015 and 2.5 ±0.085 then at 7^thweek with a mean of 2.9 ±0.1755 then declined to 1.6 ±0.957 at 4m while, IFN-γ was expressed at 2 DPV with a fold change 1.75-3.31 and at 7 DPV with fold change 1.22-1.74. ELISA of Neethling vaccinated group showed response at 30^th DPV with absorbance of 1.69 ±.07815 then by 40^thDPV with titer of 1.96 ±.09141 then at 7weeks with a mean 2.45 ±.055 then1.82±.1066 at4m PV, Then IFN-γ wasexpressedat2 days PV withafoldchange6.52-11.16andat7^th DPV withfoldchange1.22-1.78. According to the current study results, humeral and cellular immune response of two living attenuated Capripox viruses' vaccines were evaluated at the field conditions by ELISA and IFN-γ expression that proved to be reliable and sensitive techniques for assessment of vaccine potency.