Hemorrhagic septicemia (HS) is an acute, fatal septicaemic bacterial disease, affecting mainly cattle and buffalo, but it is widely considered that buffaloes are the most susceptible. The disease is an important cause of high morbidity and mortality in tropical regions of Asia, Africa and the Middle East. It is caused by Pasteurella multocida serotype B: 2 (Asian countries) and serotype E:2 (African countries). Respiratory system plays the main role in the route of transmission of the HS disease where the Pasteurella multocida enters the respiratory tract of infected animals through inhalation and passes into the bloodstream thus producing clinical signs which usually progress rapidly from fever and depression to death within hours to a few days. Because the disease course is so short, few animals can be treated in time, and recovery is rare. Outbreaks mostly occur during the changed climatic conditions (high humidity and high temperatures). This review aims to summarize the latest developments of the disease with the focus on its spread, etiology, transmission, clinical presentations, diagnostics and control measures