The present work was performed to evaluate the effects of probiotic and mineral mixture on body performance and some hematobiochemical parameters in unthrifty buffaloe calves. This experiment was done in 20 at 5 months old buffaloe calves (5 healthy calves weighing 120-150 Kgm-15 unthrifty calves weighing 80-105Kgm) belonged to privet farm in Abu Hamad city - Sharkia Province. All calves were received 1ml iovmic super /50 kgm body weight for proved all calves free from parasites. Blanced ration were formed and used during the experimental period. Each calve was received 2 kgm from formed ration and 5 kgm hay daily during 1^st month of experiment and 3 kgm from formed ration and 10 kgm hay daily during 2^nd month of experiment. At one month post ivomic injection calves were divided into 4 groups (5/each). 1^st group healthy calves (-ve control), 2^nd group unthrifty calves not treated (+ve control), 3^rd group unthrifty calves received 1ml probiotic/liter drinking water for 2 months, 4^th group unthrifty calves treated by 1ml probiotic/liter drinking water and 30ml mineral mixture for each calve daily for 2 months, calves in each groups were weighted at begin of experiment and at 1^st day post treatment for estimation weight gain and feed conversion rate. At 1^st&10^th day post treatment 3 blood samples were taken from all calves for estimation hematobiochemical parameters. Our results revealed that, diseased calves show significant reduction in body weight gain, erythrocytic count, hemoglobin, packed cell volume total and differential leukocytic count, phagocytic %, killing %, serum total proteins, albumin, α, β, γ globulins, total globulins, A/G ratio, catalase and super oxide dismutase beside increase in feed conversion rate, total lipid, cholesterol triglycerides and malondialdehyde,
Treatment unthrifty calves by probiotic alone for 2 months induce improve in body weight and hematobiochemical parameters but probiotic with mineral mixture induce superior improve hematobiochemical parameters and returned to nearly normal levels.
It could be concluded that calves suffering from unthriftness show many adverse effect in body performance and hematobiochemical. Using probiotic alone or with mineral mixture induced ameliorative effect of unthriftness and improved body performance and hematobiochemical parameters.