Sarcoptic mange is a highly contagious rabbit disease causes great economic losses. The present work was conducted with 80 adult rabbits (New-Zealand) in a two farms (private and governmental farm), where the infestation prevalence was 72.5%, affecting mouth, nose, ears and other surface body skin. Most affected rabbits were suffered from off food and body weight losses. The in vivo study aimed to estimate the efficacy of topically uses of honey Propolis mixture (Propolis in Egyptian fennel honey 20% wt/ vol) in treatment of naturally infested rabbits with Sarcoptes scabiei comparing with the already classic traditional treatment (ivermectin and sulfur ointment).Twenty (6–8 month old) of naturally infested rabbits with S. scabiei were randomly divided into four groups: the 1^st group was control untreated, the 2^nd group was honey propolis mixture topically treated once weekly, the 3^rd group was Ivermectin 1% treated with dose of 0.3 mg/kg (double dose with 15 days interval) and the 4^th group treated with sulfur ointment 20% topically once daily. Treatment course was designed up to three weeks and the treatment success was evaluated by clinical assessment, parasitological evaluation and histopathological examination of infested rabbits.
      The obtained results showed no any cure parameter in all rabbits of both the 1^st & the 3^rd groups by the terminal end study (day 21), but all rabbits of the 2^nd group honey propolis mixture showed marked acaricide efficacy (100%) with statistically highly significant difference (P<0.001) comparing with ivermectin 1% and significant difference (P < 0.05) with sulfur ointment group. By the 2^nd week post-treatment, where all rabbits 2^nd group were mite free with full clinical cure and showing 100% reduction of mites. Rabbits became healthy and body weight gain. Also, they showed marked improvement in the epidermis with absence of mites in skin samples histopathologically. Three rabbits of the 4^th group (60%) became cured by the terminal end study (day 21).
      On conclusion, our results demonstrated that topical application of honey propolis mixture in two consecutive doses (once weekly) were valuable, highly economic, safe therapeutic approach for scabies therapy in rabbits than both ivermectin1% and sulfur ointment20%. Moreover, other than the superiority of honey propolis mixture studied treatments, rabbits could be slaughtered just post treatment, while other chemical drugs need two weeks or more for with drawl post treatment.