Antibiotics were considered as an amazing gift to the human and animal healthcare sectors for the treatment of bacterial infections. Antibiotic resistance is the ability of bacteria to resist to the action of an antibiotic. Antimicrobial resistance is a worldwide problem. Antibacterial resistance results in a reduction or elimination of effectiveness of the antimicrobial agent to cure or prevent infection due to this microorganism. Macrolides resisted by gram-negative bacilli particularly members of the family Enterobacteriaceae (intrinsic resistance). Other bacteria like Staphylococci that are normally susceptible to antibiotics (penicillin) become resistant as a result of adaptation through genetic change (acquired resistance). All antibiotic-resistant bacteria survive in the presence of the antibiotic and continue to grow and multiply causing longer illness or even death. Multidrug-resistant microorganism lies in the limited number of remaining options for therapy of patients infected with these microorganisms. The major cause of antimicrobial resistance in microorganisms from humans remains the use of antimicrobials in human medicine, in the community and in hospitals and other healthcare settings. The burden of antimicrobial resistance is mainly due to antimicrobials used in food-producing animals. The current review provides information about antibiotic resistance, its mechanisms responsible for the resistance, role of animal environment and foods of animal origin in spreading the threat and finally suggestions for controlling of antibiotics resistance.