Antibiotic resistance is of  great concern  for human and animal globally. New resistance mechanisms are emerging and can spread between food-producing animals and humans all parts of the world . Antibiotic resistance is threatening our ability to treat common infectious diseases. Antibiotic resistance is accelerated by the misuse and overuse of antibiotics , so there is great demand for researches  to discover alternative substances to reduce the impact and limit the spread of resistance. Probiotics are considered to be favorable live microorganisms by the host organism by maintaining microbial homeostasis and healthy gut, morover, probiotics have been suggested as viable alternates to antibiotics and subsequently overcome antibiotic resistance and reduce the excessive use of antibiotics. In addition, providing other growth-promoting properties in the animal health and nutrition industry.