In this study, the effect of fenugreek seeds on renal injury of experimental rats was studied. A total of 20 male Albino rats, weighing 154 - 169 g, were divided into four groups of 5 each ,were randomly classified into to negative control group and renal injury groups that injected or oral with ethanol ( 10% dissolved in the drinking water) and then reclassified into 3groups (5 rats each) as follows: Control positive, fenugreek powder 10 % and fenugreek powder 15% in basal diet .At the end of experiment (4 weeks) blood samples were collected. All organs' rat was weight. kidneys were kept in formalin solution (10%) for the histopathological investigation. Blood glucose, glubulin, albumin, bilirubin, and total protein were all measured. The concentrations of creatinine, urea, and uric acid were estimated. In kidney tissues, serum antioxidant levels as well as (SOD) activity, NO, and GR levels were assessed.

Results showed significant differences among initial, final body weights, body weight gain, organs' weights and relative organs' weights, of almost the groups. Results also indicated that the decreases in SOD and the increases in (GR),(NO) levels were more detectable with increases (TSP)level. Also show improvement in the histopathological structure of the kidneys

In conclusion, fenugreek has ameliorative effect against ethanol toxicity in rats due to its antioxidant activity so, drinking or incorporating it into food