In this work, we develop, optimize and validate an electrochemical method for determining Rebamipide (REBA) using anodic differential pulse voltammetry (A-DPV) for the first time. The choice of the proper anode was determined through a comparative study between electrodes, and we found the proper one is the carbon nano-tubes that are modified with the nano form of zinc oxide electrode (ZnONP/CNT/ME). The degradant pathway of the Rebamipide was illustrated by FTIR. For the REBA quantification, we have used a 0.04M B-R buffer electrolyte solution (PH = 11.0) using the ZnONP/CNT/ME. The peak showed linearity in the range of (0.09-12.37 µg/mL), limit of detection was 0.028 µg/mL and the limit of quantification was 0.086 µg/mL. Our proposed method proved a good validation profile regarding accuracy, precision, and reproducibility in comparison to the official method. Conclusively, this work suggests the usage of a rapid, sensitive, cheap, and, most importantly, environmentally friendly protocol to determine the REBA either in the presence of its degradant, in its pharmaceutical form, or in human serum.